SMA치료제 ‘뉴시너센’ 일찍 투여·지속할수록 효과 좋아

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smn: SMA치료제 ‘뉴시너센’ 일찍 투여·지속할수록 효과 좋아

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2025-01-08 15:56 Raising SMN protein levels may be helpful early step in SMA treatment - SMA News Today
2024-08-27 07:00 Arginine methylation-enabled FUS phase separation with SMN contributes to neuronal granule formation - ScienceDirect.com
2024-06-26 06:29 SMN post-translational modifications in spinal muscular atrophy - Frontiers
2025-01-09 14:34 SpareBank 1 SMN to Call ISIN NO0010814684 at Par - TipRanks
2024-05-09 07:00 Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy - JCI
2024-06-28 07:00 Oligomerization regulates the interaction of Gemin5 with members of the SMN complex and the translation machinery - Nature.com
2024-09-18 07:00 Japan Conference 2024 - Smart Maritime Network
2024-12-30 13:01 Historic flooding and presidential candidates top the list of 2024 SMN Photos of the Year - Savannah Morning News
2024-08-22 07:00 SMN Depletion May Increase Risk of Liver Damage, Fatty Liver in SMA - AJMC.com Managed Markets Network

2024-12-20 08:00 SpareBank 1 SMN: Savings programme - subscription period closed - Finansavisen
2024-08-23 22:25 Proteomic analysis of the SMN complex reveals conserved and etiologic connections to the proteostasis network - Frontiers
2024-07-17 07:00 NEW RESEARCH REVEALS LINK BETWEEN SPINAL MUSCULAR ATROPHY (SMA) AND LIVER DAMAGE - Agency for Science, Technology and Research (A*STAR)
2024-11-06 08:00 Dubai Conference 2024 - Smart Maritime Network
2024-08-22 07:00 Ptbp2 re-expression rescues axon growth defects in Smn-deficient motoneurons - Frontiers
2024-07-30 07:00 SMN1 c.5C>G (p.Ala2Gly) missense variant, a challenging molecular SMA diagnosis associated with mild disease, preserves SMN nuclear gems in patient-specific fibroblasts - Frontiers
2024-05-27 07:00 What could be the function of the spinal muscular atrophy-causing protein SMN in macrophages? - Frontiers
2024-06-30 04:19 The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases - Frontiers
2024-02-17 16:53 Comparative genomic analysis of Lacticaseibacillus paracasei SMN-LBK from koumiss - Frontiers
2024-06-05 07:00 Looking forward to SMN in 2049 - Smoky Mountain News

2024-02-27 08:00 Germline variants in patients developing second malignant neoplasms after therapy for pediatric acute lymphoblastic leukemia—a case-control study - Nature.com
2024-11-08 08:00 Key Pathway Leading to Neurodegeneration in Early Stages of ALS Identified - University of California San Diego
2024-12-17 08:00 SpareBank 1 SMN Extends Employee Savings Scheme - TipRanks
2022-09-20 07:00 SMN controls neuromuscular junction integrity through U7 snRNP - ScienceDirect.com
2024-03-27 07:00 Second malignant neoplasms within 5 years from first primary diagnosis in pediatric oncology patients in Canada: a population-based retrospective cohort study - Frontiers
2024-12-18 08:00 Dave and Colleen’s final ‘SMN:’ KIRO colleagues, politicians say their goodbyes - MyNorthwest
2023-11-15 08:00 Nucleolar reorganization after cellular stress is orchestrated by SMN shuttling between nuclear compartments - Nature.com
2022-03-02 22:34 Axonal-SMN (a-SMN), a protein isoform of the survival motor neuron gene, is specifically involved in axonogenesis - pnas.org
2023-11-13 08:00 SMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy | Communications Biology - Nature.com
2022-09-16 07:00 A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II - Nature.com

2021-04-01 07:00 Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit - Nature.com
2024-09-13 07:00 The results are in for SMN's Student of the Week Sept. 9-12 - Savannah Morning News
2024-08-29 07:00 The results are in for SMN's Student of the Week for Aug. 26-29 - Savannah Morning News
2019-07-01 07:00 Functional characterization of SMN evolution in mouse models of SMA - Nature.com
2024-11-03 07:00 Structural Monitoring Systems Plc (ASX:SMN) Stock Rockets 25% As Investors Are Less Pessimistic Than Expected - Simply Wall St
2012-10-25 07:00 FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA - ScienceDirect.com
2024-06-17 07:00 AI Lab receives 40 million kroner - NTNU
2023-10-18 07:00 The SMN complex drives structural changes in human snRNAs to enable snRNP assembly - Nature.com
2024-03-01 08:00 Innovations in Spinal Muscular Atrophy - Health Central
2021-10-04 07:00 Biodistribution of onasemnogene abeparvovec DNA, mRNA and SMN protein in human tissue - Nature.com

2021-06-22 07:00 TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis - ScienceDirect.com
2022-03-01 20:03 SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage - pnas.org
2020-09-21 07:00 SMN-primed ribosomes modulate the translation of transcripts related to spinal muscular atrophy - Nature.com
2020-02-13 08:00 Transmission characteristics of SMN from 227 spinal muscular atrophy core families in China - Nature.com
2013-12-12 08:00 SMN Is Essential for the Biogenesis of U7 Small Nuclear Ribonucleoprotein and 3′-End Formation of Histone mRNAs - ScienceDirect.com
2019-12-10 08:00 SMN complex member Gemin3 self-interacts and has a functional relationship with ALS-linked proteins TDP-43, FUS and Sod1 - Nature.com
2018-02-01 08:00 Small-molecule flunarizine increases SMN protein in nuclear Cajal bodies and motor function in a mouse model of spinal muscular atrophy - Nature.com
2024-08-02 07:00 Industry Ink: Brooks & Dunn, Dylan Marlowe, Kameron Marlowe, Megan Moroney - musicrow.com
2024-07-30 07:00 SMN Monitors Three Potential Tropical Cyclones in the Pacific - Puerto Vallarta Daily News
2023-11-13 08:00 Indications of a ferromagnetic quantum critical point in $$\textrm{SmN}_{1-\delta }$$ SmN 1 - δ - Scientific Reports - Nature.com

2015-02-26 08:00 A new method for SMN1 and hybrid SMN gene analysis in spinal muscular atrophy using long-range PCR followed by sequencing - Nature.com
2021-11-08 08:00 (PDF) Biodistribution of onasemnogene abeparvovec DNA, mRNA and SMN protein in human tissue - ResearchGate
2020-03-25 07:00 A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation - Nature.com
2010-02-28 08:00 RETRACTED ARTICLE: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN - Nature.com
2017-02-07 08:00 Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease - ScienceDirect.com
2021-09-12 05:41 Systemic Delivery of scAAV9 Expressing SMN Prolongs Survival in a Model of Spinal Muscular Atrophy - Science
2023-02-24 08:00 A comprehensive overview of SMN and NAIP copy numbers in Iranian SMA patients - Nature.com
2024-03-01 08:00 Combining 2 SMA therapies boosts SMN protein production: Study - SMA News Today
2024-05-14 07:00 Ippopay Names Former RBI Regional Director S M N Swamy as Senior Advisor - Elets
2023-08-12 07:00 NRF2 has a splicing regulatory function involving the survival of motor neuron (SMN) in non-small cell lung cancer - Nature.com

2024-04-23 07:00 Brachytherapy for Prostate Cancer Linked to Higher Risk of Second Pelvic Malignancy - Medpage Today
2019-04-24 07:00 SMN deficiency causes pain hypersensitivity in a mild SMA mouse model through enhancing excitability of nociceptive dorsal root ganglion neurons - Nature.com
2016-06-07 07:00 Transcriptional enhancement of Smn levels in motoneurons is crucial for proper axon morphology in zebrafish - Nature.com
2017-10-24 07:00 In Vivo Translatome Profiling in Spinal Muscular Atrophy Reveals a Role for SMN Protein in Ribosome Biology - ScienceDirect.com
2023-03-17 20:00 SMN linked to SNARE complex assembly - Nature.com
2020-02-03 08:00 The Need for SMN-Independent Treatments of Spinal Muscular Atrophy (SMA) to Complement SMN-Enhancing Drugs - Frontiers
2024-11-21 08:00 Dave Ross, Colleen O'Brien will depart 'SMN,' KIRO Newsradio, - MyNorthwest
2021-08-19 07:00 Sumoylation regulates the assembly and activity of the SMN complex - Nature.com
2024-04-17 07:00 Industry Ink: Nate Smith, ACM, Bay Turner, Trey Allen - musicrow.com
2016-10-04 07:00 Survival Motor Neuron (SMN) protein is required for normal mouse liver development - Nature.com

2017-05-30 07:00 Developmental regulation of SMN expression: pathophysiological implications and perspectives for therapy development in spinal muscular atrophy - Nature.com
2021-02-24 08:00 Interaction of 7SK with the Smn complex modulates snRNP production - Nature.com
2021-05-11 07:00 A high-throughput genome-wide RNAi screen identifies modifiers of survival motor neuron protein - ScienceDirect.com
2020-02-10 08:00 Muscle-specific SMN reduction reveals motor neuron–independent disease in spinal muscular atrophy models - JCI
2017-05-17 07:00 Functional interaction between FUS and SMN underlies SMA-like splicing changes in wild-type hFUS mice - Nature.com
2011-05-25 07:00 Treatment of spinal muscular atrophy cells with drugs that upregulate SMN expression reveals inter- and intra-patient variability - Nature.com
2019-12-06 08:00 Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization - Nature.com
2016-02-02 08:00 Severe impairment of male reproductive organ development in a low SMN expressing mouse model of spinal muscular atrophy | Scientific Reports - Nature.com
2017-02-13 08:00 Gene activation of SMN by selective disruption of lncRNA-mediated recruitment of PRC2 for the treatment of spinal muscular atrophy - pnas.org
2020-11-04 08:00 SMN protein promotes membrane compartmentalization of ribosomal protein S6 transcript in human fibroblasts - Nature.com

2020-02-10 08:00 Muscle-specific SMN reduction reveals motor neuron–independent disease in spinal muscular atrophy models - JCI
2022-04-25 07:00 Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy | Gene Therapy - Nature.com
2015-12-23 08:00 SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination - Nature.com
2015-01-27 08:00 ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP - Nature.com
2019-10-07 07:00 Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment - JCI
2018-04-19 07:00 Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes - JCI
2016-08-02 07:00 A Stem Cell Model of the Motor Circuit Uncouples Motor Neuron Death from Hyperexcitability Induced by SMN Deficiency - ScienceDirect.com
2024-12-06 08:00 ASX Penny Stocks To Watch In December 2024 - Simply Wall St
2024-12-31 08:44 Historic flooding and presidential candidates top the list of 2024 SMN Photos of the Year - MSN
2015-06-30 07:00 Spinal muscular atrophy phenotype is ameliorated in human motor neurons by SMN increase via different novel RNA therapeutic approaches - Nature.com

2018-04-19 07:00 Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes - JCI
2019-12-20 02:45 A vital test for spinal muscular atrophy - Nature.com
2023-03-31 07:00 Base editing of SMN2 gene restores production of SMN protein, curing spinal muscular atrophy in mice - Medical Xpress
2024-02-02 08:00 Scientists create SMN super minigene as tool for studying SMA - SMA News Today
2024-09-19 07:00 SMN Chair/CEO Randy Goodman Sets Retirement - RAMP – Radio and Music Pros
2018-12-13 08:00 Crush incident involving a falling hatch cover on general cargo vessel SMN Explorer with loss of 1 life - GOV.UK
2010-05-05 07:00 Molecular characterization of SMN copy number derived from carrier screening and from core families with SMA in a Chinese population | European Journal of Human Genetics - Nature.com
2024-09-17 07:00 Lassiter hits 3-pt milestone as SMN clobbers Ginebra - Panay News
2011-11-20 08:00 Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins - Nature.com
2011-07-25 07:00 Of SMN in mice and men: a therapeutic opportunity - JCI

2012-06-28 07:00 A Drosophila Model of Spinal Muscular Atrophy Uncouples snRNP Biogenesis Functions of Survival Motor Neuron from Locomotion and Viability Defects - ScienceDirect.com

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